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Dr. Diehl is a Professor in the Department of Oral Biology and Director of the Center for Pharmacogenomics and Complex Disease Research (CPCDR) at the New Jersey Dental School of UMDNJ. He received his undergraduate training in Biology and Psychology at the State University of New York at Stony Brook, and completed his doctoral research in genetics at the University of Texas at Austin in 1984. He conducted postdoctoral research at the University of Massachusetts in Amherst and at the University of Michigan in Ann Arbor. He served on the faculty of the Medical College of Virginia in Richmond (1988-1993) and as Chief of the Molecular Epidemiology and Disease Indicators Branch of the National Institute of Dental and Craniofacial Research, NIH (1993-2002). Dr. Diehl's research has focused on advancing our understanding the genetic basis of diseases that have complex etiologies involving both environmental and genetic factors. He has studied both early onset and chronic forms of periodontitis, cleft lip and palate, oral cancer, nasopharyngeal carcinoma, hereditary deafness, mental illness, neurofibromatosis, and neuropathic pain. Most research is conducted directly in human patients, but some studies have involved rodent model systems. New studies currently under development focus on the genetic basis of individual differences in drug response (pharmacogenomics). For example, Dr. Diehl’s laboratory is evaluating individual differences in response to opioid drugs used for treatment of severe pain, focusing both on susceptibility to severe side effects and analgesic efficacy. Support is provided by NIH grants and contracts, and by UMDNJ Foundation and Dental School resources.RECENT PUBLICATIONS Diehl SR, Wu T, Michalowicz BS, Brooks CN, Califano JV, Burmeister JA, Schenkein HA. Quantitative measures of aggressive periodontitis show substantial heritability and consistency with traditional diagnoses. J Periodontol. 2005; 76:279-288. Erickson RP, Karolyi IJ, Diehl SR. Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. Life Sci. 2005; 76:2071-2078. Zavras AI, Pitiphat W, Wu T, Cartsos V, Lam A, Douglass CW, Diehl SR. Insulin-like growth factor II receptor gene-167 genotype increases the risk of oral squamous cell carcinoma in humans. Cancer Res. 2003; 63:296-297. Pfeiffer RM, Hildesheim A, Gail MH, Pee D, Chen CJ, Goldstein AM, Diehl SR. Robustness of inference on measured covariates to misspecification of genetic random effects in family studies. Genet Epidemiol. 2003; 24:14-23. Seltzer Z, Wu T, Max MB, Diehl SR. Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain. 2001; 93:101-106. |
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