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Jeffrey Kaplan received a Bachelor of Science degree in Biology from the University of Illinois at Chicago in 1980 and a Ph.D. in Molecular Biology from the same institution in 1985. He received postdoctoral training in the Department of Microbiology at the Albert Einstein College of Medicine, Bronx, N.Y., and in the Department of Microbiology at Columbia University, College of Physicians and Surgeons, New York, N.Y. Kaplan worked for 10 years in the Oncology Department at Wyeth Pharmaceuticlas, Pearl River, N.Y., before joining the Department of Oral Biology at New Jersey Dental School in 1999.
Kaplan's lab is studying the detachment and dispersal of bacterial cells from biofilms. The emphasis of his research is the use of matrix-degrading enzymes as research tools and potential anti-biofilm therapies.
Kaplan’s lab is currently funded by grants from the National Institute of Allergies and Infectious Diseases and from Genentech, Inc.
RECENT PUBLICATIONS
Yakandawala N, Gawande PV, LoVetri K, Romeo T, KAPLAN JB, Madhyastha S. 2009. Enhanced expression of engineered ACA-less b-1,6-N-acetlyglucosaminidae (dispersin B) in Escherichia coli. Journal of Industrial Microbiology and Biotechnology (in press).
Di Bonaventura M, Rob DeSalle R, Pop M, Nagarajan N, Figurski D, Fine DH, KAPLAN JB, Paul Planet P. 2009. Complete genome sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700. Journal of Bacteriology 191:4693-4694.
Izano EA, Shah SM, KAPLAN JB. 2009. Intercellular adhesion and biocide resistance in nontypeable Haemophilus influenzae biofilms. Microbial Pathogenesis 46:207-213.
Ganeshnarayan K, Shah SM, Libera MR, Santostefano A, KAPLAN JB. 2009. Poly-N-acetylglucosamine matrix polysaccharide impedes fluid convection and transport of the cationic surfactant cetylpyridinium chloride through bacterial biofilms. Applied and Environmental Microbiology 75:1308-1314.
Krsko P, KAPLAN JB, Libera M. 2009. Spatially controlled bacterial adhesion using surface-patterned poly(ethylene glycol) hydrogels, Acta Biomaterialia 5:589-596.
Kerrigan JE, Ragunath C, Kandra L, Gyémánt G, Lipták A, Jánossy L, KAPLAN JB, Ramasubbu N. 2008. Modeling and biochemical analysis of the activity of antibiofilm agent dispersin B. Acta Biologica Hungarica 59:439-451.
Venketaraman V, Lin AK, Le A, Kachlany SC, Connell ND, KAPLAN JB. 2008. Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans biofilm cells from macrophage killing. Microbial Pathogenesis 45:173-180.
Isaza MP, Duncan MS, KAPLAN JB, Kachlany SC. 2008. A screen for leukotoxin mutants in Aggregatibacter actinomycetemcomitans: genes of the phosphotransferase system (PTS) are required for leukotoxin biosynthesis.
Lee J-H, KAPLAN JB, Lee WY. 2008. Microfluidic devices for studying growth and removal of Staphylococcus epidermidis biofilms. Biomedical Microdevices 10:489-498.
Rupani D, Izano EA, Schreiner H, Fine DH, KAPLAN JB. 2008. Aggregatibacter actinomycetemcomitans serotype f O-polysaccharide mediates coaggregation with Fusobacterium nucleatum. Oral Microbiology and Immunology 23:127-130.
Izano EA, Sadovskaya I, Wang H, Vinogradov E, Ragunath C, Ramasubbu N, Jabbouri S, Perry MB, KAPLAN JB. 2008. Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance in Aggregatibacter actinomycetemcomitans. Microbial Pathogenesis 44:52-60.
Izano EA, Amarante MA, Kher WB, KAPLAN JB. 2008. Differential roles of poly-N-acetylglucosamine surface polysaccharide and extracellular DNA in Staphylococcus aureus and Staphylococcus epidermidis biofilms. Applied and Environmental Microbiology 74:470-476.
Rohde H, Burandt EC, Siemssen N, Frommelt L, Burdelski C, Wurster S, Scherpe S, Davies AP, Harris LG, Horstkotte MA, Knobloch JKM, Ragunath C, KAPLAN JB, Mack D. 2007. Polysaccharide intercellular adhesin and protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. Biomaterials 28:1711-1720.
Chaignon P, Sadovskaya I, Ragunath C, Ramasubbu N, KAPLAN JB, Jabbouri S. 2007. Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition. Applied Microbiology and Biotechnology 75:125-132.
Izano EA, Sadovskaya I, Vinogradov E, Mulks MH, Velliyagounder K, Ragunath C, Kher WB, Ramasubbu N, Jabbouri S, Perry MB, KAPLAN JB. 2007. Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae. Microbial Pathogenesis 43:1-9.
Izano EA, Wang H, Ragunath C, Ramasubbu N, KAPLAN JB. 2007. Detachment and killing of Aggregatibacter actinomycetemcomitans biofilms by dispersin B and SDS. Journal of Dental Research 86:618-622.
Donelli G, Francolini I, Romoli D, Guaglianone E, Piozzi A, Ragunath C, KAPLAN JB. 2007. Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes. Antimicrobial Agents and Chemotherapy 51:2733-2740.
Yu G, KAPLAN JB, Furgang D, Mansfield KG, Fine DH. 2007. A second Aggregatibacter actinomycetemcomitans autotransporter adhesin exhibits specificity for buccal epithelial cells of humans and Old World primates. Infection and Immunity 75:4440-4448.
Manuel SGA, Ragunath C, Sait HBR, Izano EA, KAPLAN JB, Ramasubbu N. 2007. Role of active-site residues of dispersin B, a biofilm-releasing b-hexosaminidase from a periodontal pathogen, in substrate hydrolysis. FEBS Journal 274:5987-5999.
KAPLAN JB, Mulks MK. 2005. Biofilm formation is prevalent among field isolates of Actinobacillus pleuropneumoniae. Veterinary Microbiology 108:89-94.
Fine DH, Velliyagounder K, Furgang D, KAPLAN JB. 2005. The Actinobacillus actinomycetemcomitans autotransporter adhesin Aae exhibits specificity for buccal epithelial cells from humans and Old World primates. Infection and Immunity 73:1947-1953.
Ramasubbu N, Thomas L, Ragunath, C, KAPLAN JB. 2005. Structural analysis of dispersin B, a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitans. Journal of Molecular Biology 349:475-486.
KAPLAN JB, Chandran R, Velliyagounder K., Fine DH, Ramasubbu N. 2004. Enzymatic detachment of Staphylococcus epidermidis biofilms. Antimicrobial Agents and Chemotherapy 48:2633-2636.
KAPLAN JB, Velliyagounder K, Chandran R, Rohde H, Mack D, Knobloch JKM, Ramasubbu N. 2004. Genes involved in the synthesis and degradation of matrix polysaccharide in Actinobacillus actinomycetemcomitans and Actinobacillus pleuropneumoniae biofilms. Journal of Bacteriology 186:8213-8220.
KAPLAN JB, Meyenhofer MF, Fine DH. 2003. Biofilm growth and detachment of Actinobacillus actinomycetemcomitans. Journal of Bacteriology 185:1399-1404.
KAPLAN JB, Chandran R, Ramasubbu N, Fine DH. 2003. Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous b-hexosaminidase activity. Journal of Bacteriology 185:4693-4698.
Schreiner HC, Sinatra K, KAPLAN JB, Furgang D, Kachlany SC, Planet PJ, Perez BA, Figurski DF, Fine DH. 2003. Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. Proceedings of the National Academy of Sciences, U.S.A. 100:7295-7300.
Velliyagounder K, KAPLAN JB, Furgang D, Legarda D, Diamond G, Parkin R, Fine DH. 2003. One of two human lactoferrin variants exhibits increased antimicrobial and transcriptional activation activities and is associated with localized juvenile periodontitis. Infection and Immunity 71:6141-6147.
KAPLAN JB, Kokeguchi S, Murayama Y, Fine DH. 2003. Sequence diversity in the major fimbrial subunit gene (flp-1) of Actinobacillus actinomycetemcomitans. Oral Microbiology and Immunology 17:354-359.
KAPLAN JB, Schreiner HS, Furgang D, Fine DH. 2002. Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. Journal of Clinical Microbiology 40:1181-1187.
KAPLAN JB, Fine DH. 2002. Biofilm dispersal of Neisseria subflava and other phylogenetically diverse oral bacteria. Applied and Environmental Microbiology 68:4943-4950.
Kachlany SC, Planet PJ, DeSalle R, Fine DH, Figurski DH, KAPLAN JB. 2001. flp-1, the first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans. Molecular Microbiology 40:542-554.
KAPLAN JB, Perry MB, MacLean LL, Furgang D, Wilson ME, Fine DH. 2001. Structural and genetic analyses of O polysaccharide from Actinobacillus actinomycetemcomitans serotype f. Infection and Immunity 69:5375-5384.
Fine DH, Furgang D, KAPLAN JB, Charlesworth J, Figurski DH. 1999. Tenacious adhesion of Actinobacillus actinomycetemcomitans strain CU1000 to salivary-coated hydroxyapatite. Archives of Oral Biology 44:1063-1076.
KAPLAN JB, Fine DH. 1998. Codon usage in Actinobacillus actinomycetemcomitans. FEMS Microbiology Letters 163:31-36.
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