|
Dr. Chinnaswamy Kasinathan is an Associate Professor in the Department of Oral Biology at the University of Medicine and Dentistry of New Jersey. He received his Ph.D. at the Postgraduate Institute of Medical Education and Research in Chandigarh, India in 1984.
His overall research is in studying post-translational modifications of proteins. Several post-translational modifications responsible for the processing of proteins have been well characterized in endoplasmic reticulum and in Golgi. But the tyrosine protein sulfation involving the transfer of sulfate from 3' phosphoadenosine 5' phosphosulfate to the hydroxyl group of tyrosine in protein has gained very little attention. The effects of tyrosine sulfaction on the secretion and biological activities of salivary proteins are being investigated. Additional research in his laboratory investigates the biochemical mechanism leading to alcoholism. Alcohol induced secretion of proteins has been well documented, however, the basic biochemical events which trigger this process are still unknown. Currently, his attention is directed in deve loping a sustained injectable drug for the treatment of narcotic drug addition using the “Gel Depot” system, which can eliminate current limitations. Gel Depot is a novel, non-toxic, poly(ethylene glycol) based hydrogel system that is injected subcutaneously. This is in sharp contrast to other products under development based on irritating poly(lactic acid) and involves painful intra-muscular injections. We contend that use of naltrexone or methadone based Gel Depot can eliminate current limitation such as patient compliance since “Gel Depot” provides minimal burst effects, reduced potential for abuse.
RECENT PUBLICATIONS
Vaidyanathan, J., Kasinathan, C., and Vaidyanathan, T.K. Biometric recognition and immunochemical assay of ligand binding to collagen. J. Adhesive Dentistry. 5:7-17, 2003.
Kasinathan, C., Vrana, K., Beretta, L., Thomas, P., Gooch, R., Worst, T., Walker; S. Xu, A. Pierre, P., Green, H., Grant, K., and Manowitz, P. The future of proteomics in the study of alcoholism. Alcoholism: Clinical and Experimental Research. 28:228-232, 2004.
Kasinathan, C., Ramaprasad, P and Sundaram, P. Indentification and characterization of tyrosylprotein sulfotransferase from human saliva. Int. J. Biol. Sci. 1:141-145, 2005.
Kasinathan, C., Jean, S., and Manowitz, P. Tyrosine sulfation of arylsulfatase A and its peptide. Protein and Peptide Letters 13:357-361, 2006.
Previous
Page
|
|
