LISA K. RYAN, Ph.D. ryanlk@umdnj.edu Office: MSB C-516 Lab: NJDS C-840 Phone: (973) 972-2624 FAX: (973) 972-0045

Dr. Lisa Ryan is currently an assistant professor in oral biology. She received her Bachelor of Science degree from Pennsylvania State University in Microbiology, her Master of Science degree from West Virginia University in Medical Microbiology, and her doctoral degree in Toxicology (specializing in immunotoxicology and respiratory toxicology) from the University of Pittsburgh Graduate School of Public Health. She did her postdoctoral fellowship in pulmonary immunology at Harvard Medical School in Massachusetts General Hospital’s Pulmonary Unit. She was a principal investigator in the Immunotoxicology Branch of EPA’s National Health and Environmental Effects Research Laboratory and was the science advisor for EPA Region 2 before coming to UMDNJ in 2000.

Her current research interests at UMDNJ have been in studying human innate immune responses to viral infection in both the oral cavity and the lung, including HSV and influenza, and modeling influenza infection in mice to study innate immune responses in vivo. Her research focuses on studying the role of virus-induced ß-defensins and their induction via toll-like receptors in plasmacytoid dendritic cells and in other cells of the immune system. Flow cytometry, immunoassays, immunohistochemistry and gene expression techniques are employed to study the role of ß-defensins in viral immunity.

The role of ß-defensins in viral innate immunity (UMDNJ Foundation).
Effects of air pollutant particles on airway host defense (to be submitted to NIH, EPA).
Human ß-defensin 1 in Oral Virus Innate Immunity (submitted to NIH)
Role of ß-defensins in influenza innate immunity (to be submitted to NIH).

RECENT PUBLICATIONS

Klein-Patel ME, Diamond G, Boniotto M, Yim S, Ryan LK. Inhibition of ß-defensin Gene Expression in Airway Epithelial Cells by Low Doses of Residual Oil Fly Ash is Mediated by Vanadium. 2006; Toxicol. Sci. (In Press).

Ryan LK, Diamond G, Amrute S, Feng Z, Weinberg A, Fitzgerald-Bocarsly PA. Detection of HBD1 Peptide in Peripheral Blood Mononuclear Cell Subpopulations by Intracellular Flow Cytometry 2003; Peptides 24:1785-1794.

Ryan LK, Copeland LR, Daniels MJ, Costa ER, Selgrade MJK. Proinflammatory and Th1 Cytokine Alterations Following Ultraviolet Radiation Enhancement of Disease due to Influenza Infection in Mice. 2002; Toxicol. Sci.67:88-97.

Suliman H, Ryan LK, Bishop LR, Folz RJ. Overexpression of Extracellular Superoxide Dismutase (ecSOD) in the Airways of Transgenic Mice Reduces the Resultant Lung Injury Induced by Primary Infection with Influenza Virus. 2001; Am. J. Physiol. Lung Cell Mol. Physiol.280: L69-L78.

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